Download Birth, Distress and Disease: Placental-Brain Interactions by Michael L. Power, Jay Schulkin PDF

By Michael L. Power, Jay Schulkin

This quantity examines the function of steroids and peptides within the legislation of being pregnant and being pregnant consequence, in addition to their long term results. while pregnant the placenta acts as a vital regulator and coordinator of maternal and fetal body structure, and on the onset of work, via its construction and legislation of steroids and peptides. Perturbations to this regulatory procedure may end up in terrible being pregnant end result, corresponding to preterm start and coffee start weight. The induction and suppression of peptides by way of steroids seems to be key to regulatory functionality in either mind and placenta.

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2003). , 2003). Expression and localization Syversen et al. (1992) showed the presence of CgA mRNA and peptide in intrauterine tissues as placental trophoblast, decidua and fetal membranes. The CgA immunoreactivity was demonstrated by immunofluorescence studies of isolated trophoblasts and decidual cells from term placentas. Double immunofluorescence of isolated trophoblasts showed colocalization of CgA with hPL and hCG. Since syncytiotrophoblasts are the placental source of hPL, that indicates that this cell is one site of CgA production.

Thus, the intraplacental mechanism of control of hormone secretion resembles in many aspects the organization of hypothalamus–pituitary–target organ axes. , 1996d). Physiological functions of these placental secretions include: (1) (2) (3) (4) 16 to maintain an equilibrium between the fetus and the mother; to provide a favorable uterine environment at implantation; to regulate fetal growth during pregnancy; to direct the appropriate signals for the timing of parturition. 1). Human placenta decisively contributes to all phases of gestation, and placental neurohormones are critical in providing a favorable uterine environment.

1993). , 1998). 4). , 2000). 4 In vitro evidences for a role of CRF on placental, maternal and fetal endocrinology. Placental CRF at the end of pregnancy stimulates fetal pituitary ACTH secretion, which in turn stimulates fetal adrenal cortisol and DHEA-S production. The increasing concentrations of cortisol, in addition to maturating enzymes in organs critical for postnatal existence, further stimulate production of placental CRF by a feed-forward mechanism. The increasing production of DHEA-S provides additional substrate for placental aromatization to estrogen, which triggers the cascade leading to labor and delivery.

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